Share on Pinterest A total protein test requires either a blood or urine sample.Ī healthcare provider administers a total protein test in a clinic or other healthcare setting. cirrhosis, involving inflammation and scarring of the liver.This is because some conditions affect the amounts of albumin or globulin in the blood.Ī low A/G ratio may be due to an overproduction of globulin, underproduction of albumin, or loss of albumin, which may indicate the following: kidney disease, such as nephrotic syndrome or glomerulonephritisĪlongside the serum total protein level, a laboratory may calculate the albumin to globulin (A/G) ratio in the bloodstream.malabsorption disorders, such as celiac disease or inflammatory bowel disease (IBD).Low serum total protein levels may suggest any of the following health conditions: inflammation from infections, such as HIV or viral hepatitis.What do high protein levels mean?Ĭonsistently high serum total protein levels can indicate the following health conditions: If protein levels are not healthy, the doctor may recommend further tests. They will analyze the results in the context of a person’s overall CMP. However, problems with the urinary tract, such as chronic kidney disease, can cause large amounts of protein to leak into the urine.Ī doctor will look at the results of the serum total protein test along with other test results to help diagnose medical conditions. The kidneys filter albumin and other proteins from the blood so that the urine may contain small amounts of protein. They include carrier proteins, enzymes, complement, and immunoglobulins (also called antibodies).Ī urine total protein test detects the amounts of protein present in the urine. They are grouped by how they migrate on electrophoresis and include α1, α2, β and γ fractions. Globulin proteins vary in size, weight, and function.It regulates oncotic pressure in the plasma to prevent water from leaking out of the blood vessels. Albumin protein accounts for half of the total protein found in blood plasma.Blood testĪ serum total protein test measures the amount of albumin and globulin present in the serum portion of the blood: The test examines protein in either urine or the liquid portion of the blood, which medial professionals call the serum. Proteins are essential for overall health, which is why routine health checkups often include a total protein test.Ī total protein test measures the total number of proteins present in body fluid. Proteins serve as building blocks for many organs, hormones, and enzymes. This blood sample is used to evaluate the ratio.Share on Pinterest The total protein test can help a doctor diagnose various conditions. The person needs to give a blood sample that is drawn from the vein in the arm by a phlebotomist. If a person experiences unexplained weight loss, fatigue or shows symptoms of liver diseases or kidney disorder, he or she is asked to take total protein or albumin globulin ratio test. It is used to evaluate different liver diseases, kidney diseases as well as check the nutritional status of a patient. Increase, decrease or normal albumin globulin ratio helps in determining the reasons for liver problems, if any.Īlbumin globulin ratio or A/G ratio is a blood test, where the albumin value is divided by the globulin value. In order to evaluate liver function, a total protein or albumin globulin ratio test is carried out. Albumin is made exclusively in the liver and globulin is formed in many sites within the body. Albumin helps in preventing blood from leaking out of the blood vessels and globulin has an important part in the immune system. Of these many types of proteins, albumin and globulin are the two major groups of protein found in blood. Blood contains different types of proteins that help in various functions of the body.
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